Dr. John Jose E - TAVI Specialist, Percutaneous Valve Interventions, Structural Heart Disease | Professor & HOU – Unit 2, Cardiology Department, Christian Medical College, Vellore Tamil Nadu – India
Dr. John Jose E - TAVI Specialist, Percutaneous Valve Interventions, Structural Heart Disease | Professor & HOU – Unit 2, Cardiology Department, Christian Medical College, Vellore Tamil Nadu – India
Dr. John Jose E - TAVI Specialist, Percutaneous Valve Interventions, Structural Heart Disease | Professor & HOU – Unit 2, Cardiology Department, Christian Medical College, Vellore Tamil Nadu – India

Research & Publications

Publications and Scientific Contributions

Dr. John Jose has contributed extensively to advancing TAVI, structural heart therapies, coronary interventions, and innovative cardiovascular treatments. His research spans leading global journals, major multicenter trials, and authoritative textbooks — influencing practice in India and internationally.

Research Impact

  • Over 50 peer-reviewed publications
  • Articles in NEJM, JACC, EuroIntervention, CCI, IJ Cardiology and others
  • Investigator in landmark global clinical trials
  • Regular international faculty and conference speaker
  • Multiple textbook chapters and national guideline contributions
Full List of Peer Reviewed Publications

  1. Clinical bioprosthetic heart valve thrombosis after transcatheter aortic valve implantation: incidence, characteristics, and treatment outcomes. John Jose, Dmitriy S. Sulimov, Mohamed El-Mawardy, Takao Sato, Abdelhakim Allali, Erik W. Holy, Björn Becker, Martin Landt, Julia Kebernik, Bettina Schwarz, Gert Richardt, Mohamed Abdel-Wahab. JACC cardiovascular Interventions 2017; 10(7):686-97. Read More
  2. Redo TAVI: initial experience at two German centres. Schmidt T1, Frerker C, Alessandrini H, Schlüter M, Kreidel F, Schäfer U, Thielsen T, Kuck KH, Jose J, Holy EW, El-Mawardy M, Allali A, Richardt G, Abdel-Wahab M. EuroIntervention. 2016 Sep 18;12(7):875-82. Read More
  3. 1-Year Outcomes After Transcatheter Aortic Valve Replacement With Balloon-Expandable Versus Self-Expandable Valves: Results From the CHOICE Randomized Clinical Trial. AbdelWahab M, Neumann FJ, Mehilli J, Frerker C, Richardt D, Landt M, Jose J, Toelg R, Kuck KH, Massberg S, Robinson DR, El-Mawardy M, Richardt G; CHOICE Investigators. J Am Coll Cardiol. 2015 Aug 18;66(7):791-800.  Read More
  4. Transfemoral TAVI devices: design overview and clinical outcomes. Abdel-Wahab M, Jose J, Richardt G. EuroIntervention. 2015 Sep;11 Suppl W:W114-8. doi: 10.4244/EIJV11SWA33. Read More
  5. Setting up a transcatheter aortic valve implantation program: Indian perspective. Jose J, Manik G, Abdel-Wahab M. Indian Heart J. 2016 Sep – Oct;68(5):732-736. Read More
  6. Balloon- or Self-Expandable TAVI: Clinical Equipoise? Jose J, Richardt G, Abdel-Wahab M. Interventional Cardiology Review, 2015;10(2):103–8. Read More
  7. MY APPROACH to Management of Aortic Stenosis in the Elderly. Richardt G, Jose J. Practice Update Cardiology July 2015. Read More
  8. Safety and Efficacy of Left Atrial Appendage Closure with the Amplatzer Cardiac Plug in Very High Stroke and Bleeding Risk Patients with Non-Valvular Atrial Fibrillation. Kebernik J, Jose J, Abdel-Wahab M, Stöcker B, Geist V, Richardt G. Cardiol Ther. 2015 Dec;4(2):167-77. doi: 10.1007/s40119-015-0053-z. Epub 2015 Nov 13. Read More
  9. Effect of strut distribution on neointimal coverage of everolimus-eluting bioresorbable scaffolds: an optical coherence tomography study. Takao Sato, John Jose, Abdelhakim Allai, Mohamed El-Mawardy, Ralph Tölg, Gert Richardt & Mohamed Abdel-Wahab. J Thromb Thrombolysis. DOI 10.1007/s11239-017-1511-3. Read More
  10. Comparison of Bailout and Planned Rotational Atherectomy for Heavily Calcified Coronary Lesions: A Single-Center Experience. Allali A, Abdel-Wahab M, Sulimov DS, Jose J, Geist V, Kassner G, Richardt G, Toelg R. J Interv Cardiol. 2017 Apr;30(2):124-133. Read More
  11. Neointimal response to everolimus-eluting bioresorbable scaffolds implanted at bifurcating coronary segments: insights from optical coherence tomography. Sato T, Jose J, El-Mawardy M, Sulimov DS, Tölg R, Richardt G, Abdel-Wahab M. Int J Cardiovasc Imaging. 2017 Feb;33(2):169-175. Read More
  12. Predictors of acute scaffold recoil after implantation of the everolimus-eluting bioresorbable scaffold: an optical coherence tomography assessment in native coronary arteries. Sato T, Jose J, El-Mawardy M, Sulimov DS, Tölg R, Richardt G, Abdel-Wahab M. Int J Cardiovasc Imaging. 2017 Feb;33(2):145-152.Read More
  13. Relationship between peri-strut low intensity areas and vascular healing response after everolimus-eluting bioresorbable scaffold implantation: An optical coherence tomography study. Sato T, Jose J, El-Mawardy M, Sulimov DS, Tölg R, Richardt G, Abdel-Wahab M. J Cardiol. 2016 Aug 9. pii: S0914-5087(16)30146-0. Read More
  14. Testosterone as a marker of coronary artery disease severity in middle aged males. Gururani K, Jose J, George PV. Indian Heart J. 2016 Dec;68 Suppl 3:S16-S20. Read More
  15. Neointimal coverage of overlapping everolimus-eluting bioresorbable scaffolds: An optical coherence tomography study in native coronary arteries. Sato T, Jose J, El-Mawardy M, Sulimov DS, Tölg R, Richardt G, Abdel-Wahab M. Int J Cardiol. 2016 Oct 15;221:243-5. Read More
  16. Follicular thyroid carcinoma with tumour thrombus extending into superior vena cava and right atrium – A case report. Geetesh Manik, John Jose, B. Hygriv Rao. Manik G, Jose J, Hygriv Rao B. Indian Heart J. 2016 Sep;68 Suppl 2:S146-S147. Read More
  17. Transjugular balloon mitral valvotomy in a patient with inferior vena-caval interruption. Jose J, Kumar V, Joseph G. JACC CardiovascInterv. 2012 Feb;5(2):243-4. Read More
  18. Infective Endocarditis presenting with ST segment elevation. Jose J, Narayanan K, Chacko ST, George OK. J HeartValveDis. 2011 Jul;20(4):468-70. Read More
  19. Assessment of right ventricular strain and strain rate in patients with severe mitral stenosis before and after balloon mitral valvuloplasty. Kumar V; Jose VJ; Pati PK; Jose J: Indian Heart J. 2014 Mar-Apr;66(2):176-82. Read More
  20. L Wave in Echo Doppler. Kumar V; Jose J; Jose VJ. Indian Heart J. 2014; 66(3):392-3. Read More
  21. Profile of incident chronic kidney disease related-mineral bone disorders in chronic kidney disease Stage 4 and 5: A hospital based cross-sectional survey. A. T. Valson, M. Sundaram, V. G. David, M. N. Deborah, S. Varughese, G. Basu, A. Mohapatra, S. Alexander, J. Jose, J. Roshan, B. Simon, G. Rebekah, V. Tamilarasi, C. K. Jacob. Indian J Nephrol. 2014 Mar;24(2):97-107. Read More
  22. High-Dose Statin Therapy in Asians: Not as Relevant as in Western Populations. V Jacob Jose, PK Pati, John Jose. Journal of Clinical and Preventive Cardiology, January 2012, Number 1. Read More
  23. Intracardiac blood-filled cysts of the heart: a rare cause of embolic stroke. Jacob JJ, Jose J, John B. Singapore Med J. 2007 May;48(5):e125-6. Read More
  24. MycophenolateMofetil in Neuropsychiatric Systemic Lupus Erythematosus. J.Jose, B.K. Paulose, Z. Vasuki, D. Danda. Indian J Med Sci, Vol. 59, No. 8, August 2005. Read More
  25. Abstracts from the World Congress of Cardiology Scientific Sessions: Oral Presentations From the WORLD CONGRESS OF CARDIOLOGY Scientific Sessions 2012: Dubai, United Arab Emirates18–21 April 2012 Circulation. 2012;125:e659-e740. Read More
  26. Postprandial angina: not always due to stenotic coronary artery disease. Ghosh GC, Jose J, George PV. BMJ Case Rep. 2017 Nov 3;2017. pii: bcr-2017-223030. doi: 10.1136/bcr-2017-223030. Read More
  27. Anomalous Left Coronary Artery from Pulmonary Artery. Heart Views : the Official Journal of the Gulf Heart Association. 2019 Jul-Sep;20(3):126-127. DOI: 10.4103/heartviews.heartviews_134_17. PMID: 31620260; PMCID: PMC6791095.. Ghosh GC, Jose J, Gururani K. Heart Views (In print).  Read More
  28. Transcatheter aortic valve implantation with a novel pre-packaged self-expandable dry-tissue transcatheter aortic valve: a case report December 2020European Heart Journal – Case Reports 5(2) DOI:10.1093/ehjcr/ytaa539. Read More
  29. Clinical evaluation of the Hydra self-expanding transcatheter aortic valve: 6 month results from the GENESIS trial. Chandra P, Jose J, Mattummal S, Mahajan AU, Govindan SC, Makhale CN, Chandra S, Shetty R, Mohanan S, John JF, Mehrotra S, Søndergaard L. Catheter Cardiovasc Interv. 2021 Aug 1;98(2):371-379. doi: 10.1002/ccd.29733. Epub 2021 Apr 20. PMID: 33876881. Read More
  30. Management of Coronary Disease in Patients with Advanced Kidney Disease. Bangalore S, Maron DJ, O’Brien SM, Fleg JL, Kretov EI, Briguori C, Kaul U, Reynolds HR, Mazurek T, Sidhu MS, Berger JS, Mathew RO, Bockeria O, Broderick S, Pracon R, Herzog CA, Huang Z, Stone GW, Boden WE, Newman JD, Ali ZA, Mark DB, Spertus JA, Alexander KP, Chaitman BR, Chertow GM, Hochman JS; ISCHEMIA-CKD Research Group. N Engl J Med. 2020 Apr 23;382(17):1608-1618. doi: 10.1056/NEJMoa1915925. Epub 2020 Mar 30. PMID: 32227756; PMCID: PMC7274537. Read More
  31. Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease. Spertus JA, Jones PG, Maron DJ, Mark DB, O’Brien SM, Fleg JL, Reynolds HR, Stone GW, Sidhu MS, Chaitman BR, Chertow GM, Hochman JS, Bangalore S; ISCHEMIA-CKD Research Group. N Engl J Med. 2020 Apr 23;382(17):1619-1628. doi: 10.1056/NEJMoa1916374. Epub 2020 Mar 30. PMID: 32227754; PMCID: PMC7255621. Read More
  32. Sharma SK, Rao RS, Chopra M, Sonawane A, Jose J, Sengottuvelu G. Myval transcatheter heart valve system in the treatment of severe symptomatic aortic stenosis. Future Cardiol. 2021 Jan;17(1):73-80. doi: 10.2217/fca-2020-0020. Epub 2020 Jul 6. PMID: 32628046. Read More
  33. Patent foramen ovale closure in India; Feasibility, challenges and mid-term outcomes. Thomson VS, Aaron S, Samson D N, Krupa J, Prabhakar AT, Jose J, George P, George OK, Joseph G, Yadav BK. Indian Heart J. 2021 Sep-Oct;73(5):656-659. doi: 10.1016/j.ihj.2021.09.001. Epub 2021 Sep 6. PMID: 34627589; PMCID: PMC8514405. Read More
  34. A System for Accurate Deployment of Unconstrained Triple-Fenestrated Aortic Arch Endografts. Joseph G, Thomson VS, Thankachen R, Kota A, George OK, Jose J, Joseph E, Sahajanandan R. J Endovasc Ther. 2022 Jan 12:15266028211067737. doi: 10.1177/15266028211067737. Epub ahead of print. PMID: 35021904. Read More
  35. 30-Day and 1-Year Outcomes With HYDRA Self-Expanding Transcatheter Aortic Valve: The Hydra CE Study. Aidietis A, Srimahachota S, Dabrowski M, Bilkis V, Buddhari W, Cheung GSH, Nair RK, Mussayev AA, Mattummal S, Chandra P, Mahajan AU, Chmielak Z, Govindan SC, Jose J, Hiremath MS, Chandra S, Shetty R, Mohanan S, John JF, Mehrotra S, Søndergaard L. JACC Cardiovasc Interv. 2022 Jan 10;15(1):93-104. doi: 10.1016/j.jcin.2021.09.004. PMID: 34991828. Read More
  36. Safety and Efficacy of Myval Implantation in Patients with Severe Bicuspid Aortic Valve Stenosis-A Multicenter Real-World Experience. Elkoumy A, Jose J, Terkelsen CJ, Nissen H, Gunasekaran S, Abdelshafy M, Seth A, Elzomor H, Kumar S, Bedogni F, Ielasi A, Dora SK, Chandra S, Parikh K, Unic D, Wijns W, Baumbach A, Mylotte D, Serruys P, Soliman O. J Clin Med. 2022 Jan 15;11(2):443. doi: 10.3390/jcm11020443. PMID: 35054137. Read More
  37. First-in-human evaluation of a novel balloon-expandable transcatheter heart valve in patients with severe symptomatic native aortic stenosis: the MyVal-1 study. Sharma SK, Rao RS, Chandra P, Goel PK, Bharadwaj P, Joseph G, Jose J, Mahajan AU, Mehrotra S, Sengottovelu G, Ajit Kumar VK, Manjunath CN, Abhaichand RK, Sethi R, Seth A; Collaborators. EuroIntervention. 2020 Aug 28;16(5):421-429. doi: 10.4244/EIJ-D-19-00413. Erratum in: EuroIntervention. 2020 Aug 28;16(5):429. PMID: 31566572. Read More
  38. Neocommissural/Coronary Alignment With a Novel Balloon Expandable Transcatheter Aortic Valve: First-in-Human Experience. Revaiah PC, Jose J, Gunasekaran S, Mandalay A, Garg S, Bhatt S, Seth A, Soliman O, Onuma Y, Serruys PW. JACC Cardiovasc Interv. 2023 Aug 1:S1936-8798(23)01053-1. doi: 10.1016/j.jcin.2023.07.012. Epub ahead of print. PMID: 37737798. Read More
  39. Transcranial Doppler Screening for Patent Foramen Ovale Closure in Cryptogenic Strokes in Young: A Single Center Experience from South India. Bal D, Ahmed Shaikh AI, Rayani M, Aaron S, Thompson VS, Jose J, Krupa J, Benjamin RN, Rajkumar JL, Prabhakar AT. J Assoc Physicians India. 2022 Oct;70(10):11-12. doi: 10.5005/japi-11001-0112. PMID: 37355867. Read More
  40. Angiographic quantification of aortic regurgitation following myval octacor implantation; independent core lab adjudication. Elkoumy A, Jose J, Terkelsen CJ, Nissen H, Gunasekaran S, Abdelshafy M, Seth A, Elzomor H, Kumar S, Bedogni F, Ielasi A, Dora SK, Chandra S, Parikh K, Unic D, Baumbach A, Serruys PW, Soliman O. Int J Cardiol. 2023 Jul 1;382:68-75. doi: 10.1016/j.ijcard.2023.04.003. Epub 2023 Apr 5. PMID: 37028710. Read More
  41. One-Year Outcomes after Myval Implantation in Patients with Bicuspid Aortic Valve Stenosis-A Multicentre Real-World Experience. Elkoumy A, Jose J, Terkelsen CJ, Nissen H, Gunasekaran S, Abdelshafy M, Seth A, Elzomor H, Kumar S, Bedogni F, Ielasi A, Dora SK, Chandra S, Parikh K, Unic D, Baumbach A, Serruys P, Soliman O. J Clin Med. 2023 Mar 20;12(6):2398. doi: 10.3390/jcm12062398. PMID: 36983397; PMCID: PMC10054138. Read More
  42. Latest-iteration balloon- and self-expandable transcatheter valves for severe bicuspid aortic stenosis: the TRITON study. Amat-Santos IJ, García-Gómez M, de Marco F, Won-Keun K, Brito J, Halim J, Jose J, Sengotuvelu G, Seth A, Terkelsen C, Protasiewicz M, Bonilla N, García B, Sánchez-Luna JP, Blasco-Turrión S, González JC, González-Bartol E, Ijsselmuiden AJJ, Gómez-Salvador I, Carrasco Moraleja M, San Román A. Rev Esp Cardiol (Engl Ed). 2023 Mar 9:S1885-5857(23)00067-1. doi: 10.1016/j.rec.2023.03.002. Epub ahead of print. PMID: 36898524. Read More
  43. Transcatheter valve-in-valve or valve-in-ring implantation with a novel balloon-expandable device in patients with bioprosthetic left side heart valves failure: 1-year follow-up from a multicenter experience. Moscarella E, Ielasi A, Mussayev A, Montorfano M, Mullassari A, Martin P, Testa L, Jose J, Ninios V, Toutouzas K, Giannini F, Kertesz A, Unic D, Nissen H, Ezhumalai B, Senguttuvan NB, Amat-Santos I, Seth A, Bedogni F, Tespili M. Int J Cardiol. 2023 Apr 1;376:35-45. doi: 10.1016/j.ijcard.2023.01.017. Epub 2023 Jan 16. PMID: 36657566. Read More
  44. Reduction of permanent pacemaker implantation by using the cusp overlap technique in transcatheter aortic valve replacement: a meta-analysis. Rawish E, Macherey S, Jurczyk D, Pätz T, Jose J, Stiermaier T, Eitel I, Frerker C, Schmidt T. Clin Res Cardiol. 2023 May;112(5):633-644. doi: 10.1007/s00392-022-02150-8. Epub 2023 Jan 19. PMID: 36656375; PMCID: PMC10160159. Read More
  45. Transcatheter Mitral Valve-in-Valve Implantation with the Balloon-Expandable Myval Device. Blasco-Turrión S, Serrador-Frutos A, Jose J, Sengotuvelu G, Seth A, Aldana VG, Sánchez-Luna JP, Gonzalez-Gutiérrez JC, García-Gómez M, Gómez-Herrero J, Aristizabal C, San Román JA, Amat-Santos IJ. J Clin Med. 2022 Sep 2;11(17):5210. doi: 10.3390/jcm11175210. PMID: 36079140; PMCID: PMC9457220. Read More
  46. Cyclophosphamide induced haemorrhagic myocarditis-pericarditis: a rare but lethal complication in the setting of allogeneic stem cell transplantation. Selvarajan S, Tammiraju S, Lionel S, Kulkarni U, Dwivedi PC, Aboobacker F, Korula A, Abraham A, Mathews V, Srivastava A, George P, Jose J, Kodiatte TA, Joseph E, George B. Bone Marrow Transplant. 2022 Sep;57(9):1464-1467. doi: 10.1038/s41409-022-01745-z. Epub 2022 Jun 27. PMID: 35760892. Read More
  47. Case report of a rare purine synthesis disorder due to 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICAR) deficiency. Joy P, Madhuri V, Palocaren T, Das S, Susan Cleave Abraham S, Korula S, Koshy B, Jose J, Chandran M, Danda S. Brain Dev. 2022 Oct;44(9):645-649. doi: 10.1016/j.braindev.2022.05.004. Epub 2022 May 28. PMID: 35637059. Read More
  48. Safety and Efficacy of Myval Implantation in Patients with Severe Bicuspid Aortic Valve Stenosis-A Multicenter Real-World Experience. Elkoumy A, Jose J, Terkelsen CJ, Nissen H, Gunasekaran S, Abdelshafy M, Seth A, Elzomor H, Kumar S, Bedogni F, Ielasi A, Dora SK, Chandra S, Parikh K, Unic D, Wijns W, Baumbach A, Mylotte D, Serruys P, Soliman O. J Clin Med. 2022 Jan 15;11(2):443. doi: 10.3390/jcm11020443. PMID: 35054137; PMCID: PMC8779274. Read More

Conference Presentations / Faculty Role

  • Faculty and speaker, EUORPCR 2023
  • Faculty and speaker, AICT Asia PCR 2023
  • Faculty and speaker, London PCR Valves 2022
  • Faculty and speaker, London PCR Valves 2020
  • Faculty and speaker, CSI 2020
  • Faculty and speaker, India Live 2019
  • Faculty, Cardiovascular Therapeutics Conference 2018
  • Faculty, India Valves 2017, 2018, 2020
  • OCT guidance for left main bifurcation PCI – KI Imaging, Korea 2016
  • Valve thrombosis after transcatheter aortic valve replacement: incidence, characteristics and outcomes (TCT 2015)
  • TAVI in a patient with degenerated stentless aortic bioprosthesis (TCT 2015)
  • Relationship between degree of device oversizing and outcomes in TAVI: CHOICE Trial insights (TCT 2015)
  • Hemodynamic support with Impella during MitraClip repair in severe LV dysfunction (TCT 2015)
  • TAVI with PCI in degenerated stentless valve with re-implanted coronaries (PCR London Valves 2015)
  • Transjugular Balloon Mitral Valvuloplasty in a Patient With Severe Scoliosis, EuroPCR 2014
  • Treatment of type-3 endoleak following EVAR with cyanoacrylate glue injection, NIC Kochi 2014
  • IABP Scholarship Case, TCT 2013, San Francisco
  • Functional tricuspid regurgitation correlates by 2D/3D echo, EuroECHO 2013
  • Endovascular treatment of thoracic aorta, Asia Pacific Vascular Society Summit 2013
  • CAD and Diabetes Management DFID Lecture 2013–2014
  • Percutaneous retrieval of dislodged ASD occluder device, NIC 2013
  • Percutaneous intervention for totally occluded Aortic Coarctation, TCT-AP 2013
  • Determinants of functional TR severity, World Congress of Cardiology 2012

Book Chapters

  1. Made in India Transcatheter heart valves CSI update 2023
  2. Selection of transcatheter aortic valve implantation prostheses. Mohamed Abdel Wahab and John Jose. Oxford Textbook of Interventional Cardiology (2 edn). Print ISBN 9780198754152. Published online Oct 2018.
  3. Coronary physiology evaluation update. Paul George, John Jose CSI update 2020
  4. Transcatheter pulmonary valve implantation. John Jose, Sudhakar P CSI update 2020
  5. Approach to low gradient severe aortic stenosis. Kerala Journal of Cardiology (2018).

Research Leadership and Trials

  • Primary on-site investigator for the multicenter Myval transcatheter heart valve trial
  • Primary on-site investigator for the multicenter HYDRA transcatheter heart valve trial and corresponding author for the GENESIS trial publication
  • Primary on-site investigator and collaborator for the multicenter ISCHEMIA-CKD trial
  • Primary on-site investigator for the Portico trial
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